Lee studied at Dong-Ah Broadcasting College, then made her entertainment debut in 1997 as a member of popular K-pop girl group Baby V.O.X.. After Baby V.O.X. disbanded in 2006, Lee decided to pursue an acting career. After joining a few stage plays and musicals, Lee was cast in the television drama It’s Okay, Daddy’s Girl (2010). She has since played supporting roles in The Greatest Love (2011), My Lover, Madame Butterfly (2012), and Monstar (2013).

In 2011, Lee was chosen Best New Actress in the TV Drama category at the 19th Korean Culture and Entertainment Awards.